LRRK2 Kinase Activity

Paper on (LRRK2).

– the paper may not be correct ,and can suggest and explanation

Question1:

In fig 3the authors provide evidence suggesting that the role of LRRK2 is to impair neurotransmitter release(NTrelease). Is this statement True or False? Support in 300words

Question 2

Describe in a couple of sentences the role of synapsin in NT release;Based on your description, how would you explain the results in fig 3A:Is the addition of IN-1 INCREASING orDECREASING the availability of Synaptic vesicles for release?Assuming the increase/decrease is mediated via synapsin, how would LRRK2 induce the increase/decrease of NT release(does it activate Synapsin’s function or inactivatesit)?(300wordsmax)

Question 3

Describe in your own words the principle of the method that produced the results in fig 2A.What was the hypothesis the authors tried to prove?(300wordsmax)

Question 4

In fig 8 the authors propose a model where inhibition of LRRK2 results in release of SV’s from the actin cytoskeleton. Do the results in fig4c support this hypothesis?Explain brieflywhy.(300words max)

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