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1, Consider the long-term effects of hyperglycemia as seen in poorly controlled diabetes. Consider factors that lead to good or poor compliance in regimens designed to decrease hyperglycemia and improve health outcomes in diabetics.Review this article(https://diabetesjournals.org/clinical/article/24/2/71/1610/Improving-Patient-Adherence )and identify the key factors that can interfere with compliance2. Discuss Grave’s Disease and the systemic manifestations and treatment of hyperthyroidism. Describe the pathophysiology, clinical manifestations, evaluation, and treatment of hypothyroidismUse at least one scholarly source other than your textbook to connect your response to national guidelines and evidence-based research in support of your ideas.